Tag Archives: Neil Alexander

Uncategorized

Nuclear Technology Brings Hope to Patients

MEDICALISOTOPESSaskatchewan cancer patients have been given a new reason to be hopeful thanks to nuclear technology.

The Royal University Hospital in Saskatoon is now receiving on-site medical isotopes thanks to the Fedoruk Centre, a cyclotron and a funding partnership between the province and the feds.

A cyclotron is a particle accelerator and it uses power to make particles radioactive. When these particles collide isotopes are created.

Medical isotopes are safe radioactive particles used to diagnose health conditions.

In total, the nuclear medicine community relies on a wide suite of medical isotopes. There are approximately 200 isotopes available for use. Each isotope has its own characteristics and the ability to provide doctors with a window into what is happening inside the body.

The isotope used to help detect medical issues such as cancer and Parkinson’s through a positron emission tomography (PET)/computerized tomography (CT) scan (PET-CT).

An isotope known as fluorine-18 is attached to a tracer to make a radiopharmaceutical. It is then injected into the patient where it moves throughout the body depending on the tracer.  In Canada, PET/CT scans use the radiopharmaceutical flurodeoxyglucose (FDG).  Approximately 60 minutes after injection, the scanning part of the procedure begins.

“FDG is a sugar and the sugar is burned up by different parts of the body at different rates,” according to Dr. Neil Alexander, executive director of the Fedoruk Centre. “In nuclear medicine, particularly in diagnostics, if you have a sugar it goes around the body and anything burning up the sugar at a great rate lights up on the scan.  As one example, cancer cells burn up sugar at a greater rate than healthy cells, allowing physicians to detect cancers and see how the disease responds to treatment.”

PET/CT scans provide doctors with vital information on the location and extent of cancer within the body. The test also allows doctors to assess the success of treatments; providing patients with a better chance at survival.

Parkinson’s disease diagnosis and research is one of the newest areas for medical isotopes and PET/CT. Early diagnosis in the case of Parkinson’s is an important step to increasing knowledge on how the disease progresses and responds to therapy.  In the case of Parkinson’s patients the scan is looking for a decrease in proteins used in the synapses, or the junctions between nerve cells, in the brain.

Until the cyclotron started producing isotopes, patients requiring a scan in Saskatchewan needed isotopes flown in from Ontario and because the radioactivity is short-lived, meaning FDG cannot be stored, daily shipments were required. The challenges of early morning production added to air transportation often led to delayed starts and cancellations, providing unreliability for patients in need of medical diagnoses.

“Up until now, all of it was coming in from Hamilton and a lot of the material had decayed so they couldn’t process as many patients,” says Alexander.

Producing locally means more reliable health care for patients, cutting wait times and diagnosing more patients sooner. It also means that Saskatchewan medical researchers have a supply readily available to expand their research programs.

Nuclear Innovation

New SMR Association to Present on November 18

The Emissions-Free Energy Working Group, Canada’s new small reactor association, will make a
presentation on the margins of next week’s Annual General Meeting of the Organization of Canadian Nuclear Industries on Nov 18 in Ajax, Ontario.  This AGM is themed on Small Modular Reactors Development and Applications.

Here’s what EFEWG Chair Neil Alexander has to say about this event:

OCI is pleased to announce that the Emissions-Free Energy Working Group (EFEWG) has chosen to use the opportunity provided by the OCI AGM and conference on small reactors to hold a follow-up meeting of its own on the work it is doing.  All members of OCI are invited to attend. The meeting is free to members of OCI and CNA but organizations are asked to limit their attendance to one or two representatives.   The meeting will be of interest to SMR vendors, potential SMR operators, EPCs seeking to build SMRs, safety and licensing consultancies and other supply-chain organizations that may benefit from the development of this new industry that will be complementary to the nation’s CANDU expertise.

 The vision of the EFEWG, a not-for-profit industry association, is a flourishing small reactor industry in Canada and it is presently identifying what must be done to turn that vision into a reality.  In the first phase of its activities it is in a dialogue with regulators, both nationally and internationally, and other stakeholders with a goal of ensuring that a framework for regulation is in place that assures public safety and is appropriate for these new technologies. 

 The meeting will start at 10:00am and will be held in one of the board rooms at the Ajax Hilton Garden Inn.  Details will be provided at the conference. The meeting will include presentations by the Chairman of EFEWG, Neil Alexander, and its Executive Director, Roger Humphries, on the activities of EFEWG and will include discussion of work that is taking place by IAEA through its Innovative Reactors and Fuel Cycles (INPRO)  program.

Uncategorized

Nuclear Imaging Revolutionizes Breast Cancer Research

Editorial - Breast cancerInnovative nuclear research may soon be able to tell in advance whether breast-cancer patients require specific hormone treatments – a breakthrough that could save a lot of time and money.

Scientists at the University of Saskatchewan, supported by the Sylvia Fedoruk Canadian Centre for Nuclear Innovation  is exploring whether radiopharmaceuticals can identify cancers associated with HER2, a protein that promotes cancer-cell growth.

HER2-positive breast cancers are less responsive than other cancer types to hormone treatment. Drugs like trastuzumab (Herceptin) and  lapatinib (Tykerb) are effective but costly. Other treatments get used first – and may not work.

The Fedoruk research, if successful, would help doctors to identify HER2-positive cancer more readily and to prescribe effective treatment – saving time, money and lives.

Dr. Humphrey Fonge, an adjunct professor in the Department of Medical Imaging at the University of Saskatchewan, is leading the research that will better identify the protein, or biomarkers, on therapy-resistant cells, like HER2.

“When a patient goes to a clinic, they would get injected with a radiopharmaceutical that would more accurately tell which protein is responsible for that cancer and that would allow the physician to more accurately determine treatment to a particular drug rather than a one-size-fits-all method,” he said.

The research is still in the animal-testing phase. Humphrey estimates it will take a “few years” before it goes to Health Canada for approval.

“It’s going to be revolutionary. It will save a lot of costs. If a patient goes to a clinic and is treated with a $70,000 drug and they don’t respond to drug, that’s a loss of $70,000.”

Not only will the imaging agent help to determine which drug therapy should be used, but it will also be able to monitor how patients respond to that therapy.

Neil Alexander, executive director of the Saskatoon-based Fedoruk Centre, said nuclear imaging is helping in cancer research as well in the fields of heart and brain research.

He calls it an area of expertise the Fedoruk Centre is developing through the Saskatchewan Centre for Cyclotron Sciences, which is leading to “great breakthroughs around the world.”

“The developments that are taking place in nuclear imaging will mean that our children will not be as terrified of diseases like cancer as we were because we will know so much more about them,” he said.

“Our ability to image them will give us that much more data both about the processes that cause cancer and how we can disrupt them and the ways that we can then treat them in order to minimize their consequences.”

Alexander said a large part of modern life would not be possible but for the development of innovative nuclear technology.

“The industry is hugely broad based and the innovations have led to the foundations of modern society,” he said.